Lead asset and pipeline
Serplulimab is a novel, fully humanized anti–PD-1 IgG4 monoclonal antibody currently being evaluated in combination with chemotherapy in the US through a confirmatory bridging study for the treatment of extensive-stage small cell lung cancer (ES-SCLC). It has received orphan drug designation from both the FDA and the European Commission. The Committee for Medicinal Products for Human Use (CHMP) in Europe has also issued a positive opinion, recommending marketing authorization for the treatment. Download more information about serplulimab to learn more:
Our clinical trials validate serplulimab as our lead asset for the treatment of ES-SCLC. ASTRUM-005 is a study with positive results that showed significant improvement compared to chemotherapy and had unprecedented mOS of 15.8 months. Fosun has initiated the ASTRIDE trial to confirm the results of ASTRUM-005 to patients with ES-SCLC in the United States.
Highlights of our capabilities, with respective opportunities associated and held by our affiliates: